![]() Hazard ratios (HRs) were used as effective measures. Main Outcomes and Measures Meta-analyses were conducted for DFS and OS. One-stage and 2-stage meta-analyses were performed. Individual participant data on DFS and OS were extracted from the published Kaplan-Meier survival curves. The following exclusion criteria were used: (1) non-RCTs, (2) studies without long-term survival outcomes of interest, and (3) studies that did not report Kaplan-Meier survival curves.ĭata Extraction and Synthesis This meta-analysis was performed in line with the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline for individual participant data development groups. Study Selection The meta-analysis included RCTs that compared laparoscopic surgery with open surgery for patients with rectal cancer and reported the outcome of disease-free survival (DFS) or overall survival (OS). Studies published in English were retrieved. Objective To compare the long-term oncologic outcomes of laparoscopic and open surgery for patients with rectal cancer.ĭata Sources PubMed, Web of Science, Embase, and Cochrane Central Register of Controlled Trials were searched from database inception to August 13, 2021. The results raised concerns regarding the effectiveness of the laparoscopic approach for patients with rectal cancer. Importance Two large randomized clinical trials (RCTs) found that laparoscopic surgery failed to yield noninferior pathologic outcomes compared with open surgery for patients with rectal cancer. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment. ![]() Clinical Implications of Basic Neuroscience. ![]() ![]()
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